Publikationen
_{Transmembran-Signaltransduktion}

Maksymenko, K.; Hatskovska, V.; Coles, M.; Aghaallaei , N.; Pashkovskaia, N.; Borbarán-Bravo, N.; Pilz, M.; Bucher, P.; Volz, M.; Pereira, J. et al.; Hartmann, M.; Tabatabai, G.; Feucht, J.; Liebau, S.; Müller, P.; Lupas, A.; Skokowa, J.; ElGamacy, M.: A Complementarity-Based Approach to De Novo Binder Design. Advanced Science 12 (13), e02015 (2025)

Boudrioua, A.; Joiner, J.; Grin, I.; Kronenberger, T.; Korotkov, V.; Steinchen, W.; Kohler, A.; Schminke, S.; Schulte, J.-C.; Pietsch, M. et al.; Naini, A.; Kalverkamp, S.; Hotop, S.-K.; Coyle, T.; Piselli, C.; Coles, M.; Rox, K.; Marschal, M.; Bange, G.; Flieger, A.; Poso, A.; Brönstrup, M.; Hartmann, M.; Wagner, S.: Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity. Science Advances 11 (15), eadr5235 (2025)

Klett, T.; Stahlecker, J.; Jaag, S.; Masberg, B.; Knappe, C.; Lämmerhofer, M.; Coles, M.; Stehle, T.; Boeckler, F.: Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution. ACS Pharmacology & Translational Science 7 (12), S. 3984 - 3999 (2024)

Stahlecker, J.; Klett, T.; Schwer, M.; Jaag, S.; Dammann, M.; Ernst, L.; Braun, M.; Zimmermann, M.; Kramer, M.; Lämmerhofer, M. et al.; Stehle, T.; Coles, M.; Boeckler, F.: Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C. RSC Medicinal Chemistry 13 (12), S. 1575 - 1586 (2022)

Dammann, M.; Stahlecker, J.; Zimmermann, M.; Klett, T.; Rotzinger, K.; Kramer, M.; Coles, M.; Stehle, T.; Boeckler, F.: Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes. Journal of Medicinal Chemistry 65 (21), S. 14539 - 14552 (2022)

Escobedo, A.; Piccirillo, J.; Aranda, J.; Diercks, T.; Mateos, B.; Garcia-Cabau, C.; Sánchez-Navarro, M.; Topal, B.; Biesaga, M.; Staby, L. et al.; Kragelund, B.; García, J.; Millet, O.; Orozco, M.; Coles, M.; Crehuet, R.; Salvatella, X.: A glutamine-based single α-helix scaffold to target globular proteins. Nature Communications 13 (1), 7073 (2022)

Skokowa, J.; Hernandez Alvarez, B.; Coles, M.; Ritter, M.; Nasri, M.; Haaf, J.; Aghaallaei, N.; Xu, Y.; Mir, P.; Krahl, A.-C. et al.; Rogers, K.; Maksymenko, K.; Bajoghli, B.; Welte, K.; Lupas, A.; Müller, P.; ElGamacy, M.: A topological refactoring design strategy yields highly stable granulopoietic proteins. Nature Communications 13 (1), 2948 (2022)

Lupas, A.; Pereira, J.; Alva, V.; Merino, F.; Coles, M.; Hartmann, M.: The breakthrough in protein structure prediction. Biochemical Journal 478 (10), S. 1885 - 1890 (2021)

Hernandez Alvarez, B.; Skokowa, J.; Coles, M.; Mir, P.; Nasri, M.; Weidmann, L.; Rogers, K.; Welte, K.; Lupas, A.; Müller, P. et al.; ElGamacy, M.: Design of novel granulopoietic proteins by topological rescaffolding. PLoS Biology 18 (12), e3000919 (2020)

Toledo-Patiño, S.; Chaubey, M.; Coles, M.; Höcker, B.: Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor. Biochemistry 58 (48), S. 4790 - 4793 (2019)

ElGamacy, M.; Riss, M.; Zhu, H.; Truffault, V.; Coles, M.: Mapping Local Conformational Landscapes of Proteins in Solution. Structure 27 (5), S. 853 - 865 (2019)

Adlakha, J.; Karamichali, I.; Sangwallek, J.; Deiss, S.; Bär, K.; Coles, M.; Hartmann, M.; Lupas, A.; Hernandez Alvarez, B.: Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles. Structure 27 (3), S. 464 - 475 (2019)

ElGamacy, M.; Coles, M.; Lupas, A.: Asymmetric protein design from conserved supersecondary structures. Journal of Structural Biology 204 (3), S. 380 - 387 (2018)

ElGamacy, M.; Coles, M.; Ernst, P.; Zhu, H.; Hartmann, M.; Plückthun, A.; Lupas, A.: An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture. ACS Synthetic Biology 7 (9), S. 2226 - 2235 (2018)

Zhu, H.; Sepulveda, E.; Hartmann, M.; Kogenaru, M.; Ursinus, A.; Sulz, E.; Albrecht, R.; Coles, M.; Martin, J.; Lupas, A.: Origin of a folded repeat protein from an intrinsically disordered ancestor. eLife 5 (26), e16761 (2016)

Enthart, A.; Klein, C.; Dehner, A.; Coles, M.; Gemmecker, G.; Kessler, H.; Hagn, F.: Solution structure and binding specificity of the p63 DNA binding domain. Scientific Reports 6, 26707 (2016)

Pozzi, R.; Coles, M.; Linke, D.; Kulik, A.; Nega, M.; Wohlleben, W.; Stegmann, E.: Distinct mechanisms contribute to immunity in the lantibiotic NAI-107 producer strain Microbispora ATCC PTA-5024. Environmental Microbiology 18 (1), S. 118 - 132 (2016)

Korycinski, M.; Albrecht, R.; Ursinus, A.; Hartmann, M.; Coles, M.; Martin, J.; Dunin-Horkawicz, S.; Lupas, A.: STAC: A New Domain Associated with Transmembrane Solute Transport and Two-Component Signal Transduction Systems. Journal of Molecular Biology 427 (20), S. 3327 - 3339 (2015)

Hartmann, M.; Boichenko, I.; Coles, M.; Lupas, A.; Hernandez Alvarez, B.: Structural dynamics of the cereblon ligand binding domain. PLoS One 10 (5), e0128342 (2015)

Scharfenberg, F.; Serek-Heuberger, J.; Coles, M.; Hartmann, M.; Habeck, M.; Martin, J.; Lupas, A.; Alva, V.: Structure and evolution of N-domains in AAA metalloproteases. Journal of Molecular Biology 427 (4), S. 910 - 923 (2015)