Publications
_{Protein Bioinformatics}

Hu, Y.; Schwab, S.; Qiu, K.; Zhang, Y.; Bär, K.; Reichle, H.; Panzera, A.; Lupas, A.; Hartmann, M.; Dame, R. et al.; Alva, V.; Hernandez Alvarez, B.: DNA Wrapping by a Tetrameric Bacterial Histone. Nature Communications 16, 11108 (2025)

Isbilir, B.; von Kügelgen, A.; Alva, V.; Bharat, T.: Assembly, architecture and functional roles of microbial surface layers. Nature Reviews Microbiology Epub ahead (2025)

Sleutel, M.; Sonani, R.; Miller, J.; Wang, F.; Gonzalez Socorro, A.; Chen, Y.; Martin, R.; Demeler, B.; Rudolph, M.; Alva, V. et al.; Remaut, H.; Egelman, E.; Conticello, V.: Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae. Nature Communications 16, 9082 (2025)

Samir, S.; Elshereef, A.; Alva, V.; Hahn, J.; Eck, F.; Celma, L.; Lopes, E.; Thormann, K.; Dubnau, D.; Galperin, M. et al.; Selim, K.: ComFB, a new widespread family of c-di-NMP receptor proteins. Proceedings of the National Academy of Sciences of the United States of America 122 (38), e2513041122 (2025)

Schwab, S.; Hu, Y.; Hernandez Alvarez, B.; Alva, V.; Dame, R.: Histone-mediated chromatin organization in prokaryotes and viruses. Trends in Biochemical Sciences 50 (8), pp. 695 - 706 (2025)

Isbilir, B.; Yeates, A.; Alva, V.; Bharat, T.: Mapping the ultrastructural topology of the corynebacterial cell surface. PLOS Biology 23 (4), e3003130 (2025)

Rados, T.; Leland, O.; Escudeiro, P.; Mallon, J.; Andre, K.; Caspy, I.; von Kügelgen, A.; Stolovicki, E.; Nguyen, S.; Patop, I. et al.; Rangel, T.; Kadener, S.; Renner, L.; Thiel, V.; Soen, Y.; Bharat, T.; Alva, V.; Bisson, A.: Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea. Science 388 (6742), pp. 109 - 115 (2025)

Curtis, Z.; Escudeiro, P.; Mallon, J.; Leland, O.; Rados , T.; Dodge, A.; Andre, K.; Kwak, J.; Yun, K.; Issac, B. et al.; Martinez Pastor, M.; Schmid, A.; Pohlschroder, M.; Alva, V.; Bisson, A.: Halofilins as Emerging Bactofilin Families of Archaeal Cell Shape Plasticity Orchestrators. Proceedings of the National Academy of Sciences of the United States of America 121 (40), e2401583121 (2024)

Schwab, S.; Hu, Y.; van Erp, B.; Kajili, M.; Hartmann, M.; Hernandez-Alvarez, B.; Alva, V.; Boyle, A.; Dame, R.: Histones and histone variant families in prokaryotes. Nature Communications 15 (1), 7950 (2024)

Hu, Y.; Schwab, S.; Deiss, S.; Escudeiro, P.; van Heesch, T.; Joiner, J.; Vreede, J.; Hartmann, M.; Lupas, A.; Hernandez Alvarez, B. et al.; Alva, V.; Dame, R.: Bacterial histone HBb from Bdellovibrio bacteriovorus compacts DNA by bending. Nucleic Acids Research 52 (14), gkae485, pp. 8193 - 8204 (2024)

Selim, K.; Alva, V.: PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis. Current Opinion in Microbiology 79, 102453 (2024)

Bharat, T.; Tocheva, E.; Alva, V.: The cell envelope architecture of Deinococcus: HPI forms the S-layer and SlpA tethers the outer membrane to peptidoglycan. Proceedings of the National Academy of Sciences of the United States of America 120 (51), e2305338120 (2023)

Kaminski, K.; Ludwiczak, J.; Pawlicki, K.; Alva, V.; Dunin-Horkawicz, S.: pLM-BLAST: distant homology detection based on direct comparison of sequence representations from protein language models. Bioinformatics 39 (10), btad579 (2023)

Zibat, A.; Zhang, X.; Dickmanns, A.; Stegmann, K.; Dobbelstein, A.; Alachram, H.; Soliwoda, R.; Salinas, G.; Görlich, D.; Kschischo, M. et al.; Wollnik, B.; Dobbelstein, M.: N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody. iScience 26 (10), 107786 (2023)

Böhning, J.; Dobbelstein, A.; Sulkowski, N.; Eilers, K.; von Kügelgen, A.; Tarafder, A.; Peak-Chew, S.-Y.; Skehel, M.; Alva, V.; Filloux, A. et al.; Bharat, T.: Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa. PLoS Pathogens 19 (4), e1011177 (2023)

von Kügelgen, A.; van Dorst, S.; Yamashita, K.; Sexton, D.; Tocheva, E.; Murshudov, G.; Alva, V.; Bharat, T.: Interdigitated immunoglobulin arrays form the hyperstable surface layer of the extremophilic bacterium Deinococcus radiodurans. Proceedings of the National Academy of Sciences of the United States of America 120 (16), e2215808120 (2023)

von Kügelgen, A.; van Dorst, S.; Alva, V.; Bharat, T.: A multidomain connector links the outer membrane and cell wall in phylogenetically deep-branching bacteria. Proceedings of the National Academy of Sciences of the United States of America 119 (33), e2203156119 (2022)

Elhabashy, H.; Merino, F.; Alva, V.; Kohlbacher, O.; Lupas, A.: Exploring protein-protein interactions at the proteome level. Structure 30 (4), pp. 462 - 475 (2022)

von Kügelgen, A.; Alva, V.; Bharat, T.: Complete atomic structure of a native archaeal cell surface. Cell Reports 37 (8), 110052 (2021)

Pereira, J.; Alva, V.: How do I get the most out of my protein sequence using bioinformatics tools? Acta Crystallographica Section D: Structural Biology 77 (9), pp. 1116 - 1126 (2021)