Publications
_{Molecular Recognition and Catalysis}

Maksutova, A.; Geiger, T.; Cianni, L.; Pieńkowska, D.; Gerhartz, J.; Read, L.; Bricelj, A.; Herrmann, A.; Nelles, M.; Ng, Y. et al.; Hartmann, M.; Krönke, J.; Sosič, I.; Nowak, R.; Gütschow , M.; Steinebach, C.: A Facile Protocol for C(sp2)-C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands. ChemMedChem 21 (4), e202500929 (2026)

Kretsch, R.; Albrecht, R.; Andersen, E.; Chen, H.-A.; Chiu, W.; Das, R.; Gezelle, J.; Hartmann, M.; Höbartner, C.; Hu, Y. et al.; Jadhav, S.; Johnson, P.; Jones, C.; Koirala, D.; Kristoffersen, E.; Largy, E.; Lewicka, A.; Mackereth, C.; Marcia, M.; Nigro, M.; Ohja, M.; Piccirilli, J.; Rice, P.; Shin, H.; Steckelberg, A.-L.; Su, Z.; Srivastava, Y.; Wang, L.; Wu, Y.; Xie, J.; Zwergius, N.; Moult, J.; Kryshtafovych, A.: Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers. Proteins: Structure, Function, and Bioinformatics 94 (1), pp. 51 - 78 (2026)

Levashova, E.; Bischof, L.; Bunev, A.; Sapegin , A.; Grygor'eva, O.; Kudinev, A.; Ebeling, S.; Tatarinov, I.; Dar'in, D.; Kantin, G. et al.; Hartmann, M.; Kalinin, S.: Extending the chemical space of glutarimide-based cereblon ligands through an efficient Rh(II)-catalyzed X-H insertion reaction. European Journal of Medicinal Chemistry 301, 118235 (2026)

Hartmann, M.: Writing the CRBN degron. Nature Chemical Biology Epub ahead (2025)

Hu, Y.; Schwab, S.; Qiu, K.; Zhang, Y.; Bär, K.; Reichle, H.; Panzera, A.; Lupas, A.; Hartmann, M.; Dame, R. et al.; Alva, V.; Hernandez Alvarez, B.: DNA Wrapping by a Tetrameric Bacterial Histone. Nature Communications 16, 11108 (2025)

Wagner, B.; Steuer-Lodd, K.; Geibel, C.; Stadelmann, A.; Rapp, J.; Link, H.; Schramm, T.; Boodaghian, N.; Hsiao, A.; Nussbaum, E. et al.; Grenzendorfer, H.-P.; Albrecht, R.; Hartmann, M.; Forchhammer, K.; Selim, K.; Hughes, C.; Petras, D.: Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding. Proceedings of the National Academy of Sciences of the United States of America 122 (48), e2509468122 (2025)

Maksymenko, K.; Hatskovska, V.; Coles, M.; Aghaallaei , N.; Pashkovskaia, N.; Borbarán-Bravo, N.; Pilz, M.; Bucher, P.; Volz, M.; Pereira, J. et al.; Hartmann, M.; Tabatabai, G.; Feucht, J.; Liebau, S.; Müller, P.; Lupas, A.; Skokowa, J.; ElGamacy, M.: A Complementarity-Based Approach to De Novo Binder Design. Advanced Science 12 (13), e02015 (2025)

Wittenburg, S.; Zuleeg, M.; Peter, K.; Lemnitzer, P.; Voget, R.; Bricelj, A.; Gobec, M.; Dierlamm, N.; Braun, M.; Geiger, T. et al.; Heim, C.; Stakemeier, A.; Wagner, K.; Nowak, R.; Hartmann, M.; Sosič, I.; Gütschow, M.; Krönke, J.; Steinebach, C.: Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability. Journal of Medicinal Chemistry 68 (15), pp. 15711 - 15737 (2025)

Hartmann, M.: Expanding the reach of molecular glue degraders. Science 389 (6755), pp. 32 - 33 (2025)

Boudrioua, A.; Joiner, J.; Grin, I.; Kronenberger, T.; Korotkov, V.; Steinchen, W.; Kohler, A.; Schminke, S.; Schulte, J.-C.; Pietsch, M. et al.; Naini, A.; Kalverkamp, S.; Hotop, S.-K.; Coyle, T.; Piselli, C.; Coles, M.; Rox, K.; Marschal, M.; Bange, G.; Flieger, A.; Poso, A.; Brönstrup, M.; Hartmann, M.; Wagner, S.: Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity. Science Advances 11 (15), eadr5235 (2025)

Ananevaa, A.; Kantin, G.; Dar’in, D.; Bunev, A.; Ebeling, S.; Herrmann, A.; Hartmann, M.; Kalinin, S.; Bakulina, O.: Catalytic Castagnoli–Cushman reaction-based synthesis of tetrahydroisoquinolone–glutarimide dyads and their evaluation as potential cereblon ligands. Mendeleev Communications 35 (3) (2025)

Piselli, C.: How to isolate channel-forming membrane proteins using the E. coli expression system. Nature Protocols 20 (2), pp. 462 - 479 (2025)

Khuzhakhmetova, L.; Ananeva, A.; Gantin, G.; Dar’in, D.; Bunev, A.; Ebeling, S.; Herrmann, A.; Hartmann, M.; Kalinin, S.; Bakulina, O.: Synthesis of α-(azidomethyl)glutarimide and its applicationin construction of potential Cereblon ligands via the CuAAC reaction. Mendeleev Communications 35 (1), pp. 69 - 72 (2025)

Ullrich, T.; Klimenkova, O.; Pollmann, C.; Lasram, A.; Hatskovska, V.; Maksymenko, K.; Milijaš-Jotić, M.; Schenk, L.; Lengerke, C.; Hartmann, M. et al.; Piehler, J.; Skokowa, J.; ElGamacy, M.: A Strategy to Design Protein-based Antagonists Against Type I Cytokine Receptors. PLOS Biology (accepted)

Schwab, S.; Hu, Y.; van Erp, B.; Kajili, M.; Hartmann, M.; Hernandez-Alvarez, B.; Alva, V.; Boyle, A.; Dame, R.: Histones and histone variant families in prokaryotes. Nature Communications 15 (1), 7950 (2024)

Hu, Y.; Schwab, S.; Deiss, S.; Escudeiro, P.; van Heesch, T.; Joiner, J.; Vreede, J.; Hartmann, M.; Lupas, A.; Hernandez Alvarez, B. et al.; Alva, V.; Dame, R.: Bacterial histone HBb from Bdellovibrio bacteriovorus compacts DNA by bending. Nucleic Acids Research 52 (14), gkae485, pp. 8193 - 8204 (2024)

Selim, K.; Alva, V.: PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis. Current Opinion in Microbiology 79, 102453 (2024)

Shevalev, O.; Bischof, L.; Sapegin, A.; Bunev, A.; Grigoreva, O.; Kantin , G.; Kalinin, S.; Hartmann, M.: Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode. European Journal of Medicinal Chemistry 270, 116328 (2024)

Hartmann, M.: TRIM for Tissue Specificity. ACS Medicinal Chemistry Letters 15 (1), pp. 4 - 5 (2024)

Joiner, J.; Steinchen, W.; Mozer, N.; Kronenberger, T.; Bange, G.; Poso, A.; Wagner, S.; Hartmann, M.: HilE represses the activity of the Salmonella virulence regulator HilD via a mechanism distinct from that of intestinal long-chain fatty acids. The Journal of Biological Chemistry 299 (12), 105387 (2023)