Publications

Chen, T.-W.; Liao, H.-W.; Noble, M.; Siao, J.-Y.; Chang, C.-T.: Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions. eLife 13, RP94811 (2024)

Weber, R.; Chang, C.-T.: Human DDX6 regulates translation and decay of inefficiently translated mRNAs. eLife 13, RP92426 (2024)

Weber, R.; Kleemann, L.; Hirschberg, I.; Chung, M.-Y.; Valkov, E.; Igreja, C.: DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5' leaders. Nature Communications 13 (1), 7510 (2022)

Xia, S.; Ventura, I.; Blaha, A.; Sgromo, A.; Han, S.; Izaurralde, E.; Long, M.: Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation. Molecular Biology and Evolution 39 (1), msab296 (2022)

Shirsekar, G.; Devos, J.; Latorre, S.; Blaha, A.; Queiroz Dias, M.; González Hernando, A.; Lundberg, D.; Burbano, H.; Fenster, C.; Weigel, D.: Multiple Sources of Introduction of North American Arabidopsis thaliana from across Eurasia. Molecular Biology and Evolution 38 (12), pp. 5328 - 5344 (2021)

Chen, Y.; Khazina, E.; Izaurralde, E.; Weichenrieder, O.: Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex. Nucleic Acids Research (London) 49 (11), pp. 6489 - 6510 (2021)

Enwerem, I.; Elrod, N.; Chang, C.-T.; Lin, A.; Ji, P.; Bohn, J.; Levdansky, Y.; Wagner, E.; Valkov, E.; Goldstrohm, A.: Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome. RNA 27 (4), pp. 44 - 464 (2021)

Weber, R.; Chung, M.-Y.; Keskeny, C.; Zinnall, U.; Landthaler, M.; Valkov, E.; Izaurralde, E.; Igreja, C.: 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay. Cell Reports 33 (2), 108262 (2020)

Ferruz, N.; Lobos, F.; Lemm, D.; Toledo-Patino, S.; Farías-Rico, J.; Schmidt, S.; Höcker, B.: Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design. Journal of Molecular Biology 432, pp. 3898 - 3914 (2020)

Räsch, F.; Weber, R.; Izaurralde, E.; Igreja, C.: 4E-T-bound mRNAs are stored in a silenced and deadenylated form. Genes and Development 34 (11-12), pp. 847 - 860 (2020)

Arvola, R.; Chang, C.-T.; Buytendorp, J.; Levdansky, Y.; Valkov, E.; Freddolino, P.; Goldstrohm, A.: Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs. Nucleic Acids Research (London) 48 (4), pp. 1843 - 1871 (2020)

Toledo-Patiño, S.; Chaubey, M.; Coles, M.; Höcker, B.: Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor. Biochemistry 58 (48), pp. 4790 - 4793 (2019)

Peter, D.; Ruscica, V.; Bawankar, P.; Weber, R.; Helms, S.; Valkov, E.; Igreja, C.; Izaurralde, E.: Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression. Genes and Development 33 (19-20), pp. 1355 - 1360 (2019)

Chang, C.-T.; Muthukumar, S.; Weber, R.; Levdansky, Y.; Chen, Y.; Bhandari, D.; Igreja, C.; Wohlbold, L.; Valkov, E.; Izaurralde, E.: A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay. Nucleic Acids Research (London) 47 (17), pp. 9282 - 9295 (2019)

Hanet, A.; Räsch, F.; Weber, R.; Ruscica, V.; Fauser, M.; Raisch, T.; Kuzuoglu-Öztürk, D.; Chang, C.-T.; Bhandari, D.; Igreja, C. et al.; Wohlbold, L.: HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Life science alliance 2 (5), e201900405 (2019)

Raisch, T.; Chang, C.-T.; Levdansky, Y.; Muthukumar, S.; Raunser, S.; Valkov, E.: Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation. Nature Communications 10, 3173 (2019)

Ruscica, V.; Bawankar, P.; Peter, D.; Helms, S.; Igreja, C.; Izaurralde, E.: Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression. Nucleic Acids Research (London) 47 (13), pp. 7035 - 7048 (2019)

Buchta, D.; Füzik, T.; Hrebík, D.; Levdansky, Y.; Sukeník, L.; Mukhamedova, L.; Moravcová, J.; Vácha, R.; Plevka, P.: Enterovirus particles expel capsid pentamers to enable genome release. Nature Communications 10, 1138 (2019)

Keskeny, C.; Raisch, T.; Sgromo, A.; Igreja, C.; Bhandari, D.; Weichenrieder, O.; Izaurralde, E.: A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex. Genes and Development 33 (3-4), pp. 236 - 252 (2019)

Raisch, T.; Sandmeir, F.; Weichenrieder, O.; Valkov, E.; Izaurralde, E.: Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex. Journal of Structural Biology 204 (3), pp. 388 - 395 (2018)