Publications of E Izaurralde

Fromm, S.; Truffault, V.; Kamenz, J.; Braun, J.; Hoffmann, N.; Izaurralde, E.; Sprangers, R.: The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO Journal 31 (2), pp. 279 - 290 (2012)

Braun, J.; Huntzinger, E.; Fauser, M.; Izaurralde, E.: GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Molecular Cell 44 (1), pp. 120 - 133 (2011)

Igreja, C.; Izaurralde, E.: CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes and Development 25 (18), pp. 1955 - 1967 (2011)

Boland, A.; Huntzinger, E.; Schmidt, S.; Izaurralde, E.; Weichenrieder, O.: Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proceedings of the National Academy of Sciences of the United States of America 108 (26), pp. 10466 - 10471 (2011)

Huntzinger, E.; Izaurralde, E.: Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nature Reviews Genetics 12 (2), pp. 99 - 110 (2011)

Huntzinger, E.; Braun, J.; Heimstädt, S.; Zekri, L.; Izaurralde, E.: Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO Journal 29 (24), pp. 4146 - 4160 (2010)

Kashima, I.; Jonas, S.; Jayachandran, U.; Buchwald, G.; Conti, E.; Lupas, A.; Izaurralde, E.: SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes and Development 24 (21), pp. 2440 - 2450 (2010)

Boland, A.; Tritschler, F.; Heimstädt, S.; Izaurralde, E.; Weichenrieder, O.: Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Reports 11 (7), pp. 522 - 527 (2010)

Braun, J.; Tritschler, F.; Haas, G.; Igreja, C.; Truffault, V.; Weichenrieder, O.; Izaurralde, E.: The C‐terminal α–α superhelix of Pat is required for mRNA decapping in metazoa. EMBO Journal 29 (14), pp. 2368 - 2380 (2010)

Tritschler, F.; Huntzinger, E.; Izaurralde, E.: Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nature Reviews Molecular Cell Biology 11 (5), pp. 379 - 384 (2010)

Haas, G.; Braun, J.; Igreja, C.; Tritschler, F.; Nishihara, T.; Izaurralde, E.: HPat provides a link between deadenylation and decapping in metazoa. The Journal of Cell Biology: JCB 189 (2), pp. 289 - 302 (2010)

Tritschler, F.; Braun, J.; Motz, C.; Igreja, C.; Haas, G.; Truffault, V.; Izaurralde, E.; Weichenrieder, O.: DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proceedings of the National Academy of Sciences of the United States of America 106 (51), pp. 21591 - 21596 (2009)

Zekri, L.; Huntzinger, E.; Heimstädt, S.; Izaurralde, E.: The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Molecular and Cellular Biology (Washington, DC) 29 (23), pp. 6220 - 6231 (2009)

Eulalio, A.; Tritschler, F.; Izaurralde, E.: The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA: A Publication of the RNA Society 15 (8), pp. 1433 - 1442 (2009)

Wittkopp, N.; Huntzinger, E.; Weiler, C.; Saulière, J.; Schmidt, S.; Sonawane, M.; Izaurralde, E.: Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Molecular and Cellular Biology (Washington, DC) 29 (13), pp. 3517 - 3528 (2009)

Eulalio, A.; Helms, S.; Fritzsch, C.; Fauser, M.; Izaurralde, E.: A C-terminal silencing domain in GW182 is essential for miRNA function. RNA: A Publication of the RNA Society 15 (6), pp. 1067 - 1077 (2009)

Hansen, K.; Lareau, L.; Blanchette, M.; Green, R.; Meng, Q.; Rehwinkel, J.; Gallusser, F.; Izaurralde, E.; Rio, D.; Dudoit, S.: Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila. PLoS Genetics 6 (5), e1000525 (2009)

Izaurralde, E.: Freedom versus constraint in protein function. Nature Reviews Molecular Cell Biology 10 (6), p. 372 (2009)

Lazzaretti, D.; Tournier, I.; Izaurralde, E.: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA: A Publication of the RNA Society 15 (6), pp. 1059 - 1066 (2009)

Eulalio, A.; Tritschler, F.; Büttner, R.; Weichenrieder, O.; Izaurralde, E.; Truffault, V.: The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Research (London) 37 (9), pp. 2974 - 2983 (2009)