Publications of E Izaurralde

Peter, D.; Igreja, C.; Weber, R.; Wohlbold, L.; Weiler, C.; Ebertsch, L.; Weichenrieder, O.; Izaurralde, E.: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Molecular Cell 57 (6), pp. 1074 - 1087 (2015)

Igreja, C.; Peter, D.; Weiler, C.; Izaurralde, E.: 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. Nature Communications 5, 4790 (2014)

Jonas, S.; Christie, M.; Peter, D.; Bhandari, D.; Loh, B.; Huntzinger, E.; Weichenrieder, O.; Izaurralde, E.: An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nature Structural and Molecular Biology 21 (7), pp. 599 - 608 (2014)

Chen, Y.; Boland, A.; Kuzuoğlu-Öztürk, D.; Bawankar, P.; Loh, B.; Chang, C.-T.; Weichenrieder, O.; Izaurralde, E.: A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Molecular Cell 54 (5), pp. 737 - 750 (2014)

Bhandari, D.; Raisch, T.; Weichenrieder, O.; Jonas, S.; Izaurralde, E.: Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes and Development 28 (8), pp. 888 - 901 (2014)

Chang, C.-T.; Bercovich, N.; Loh, B.; Jonas, S.; Izaurralde, E.: The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Research (London) 42 (8), pp. 5217 - 5233 (2014)

Jonas, S.; Izaurralde, E.: The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes and Development 27 (24), pp. 2628 - 2641 (2013)

Boland, A.; Chen, Y.; Raisch, T.; Jonas, S.; Kuzuoğlu-Öztürk, D.; Wohlbold, L.; Weichenrieder, O.; Izaurralde, E.: Structure and assembly of the NOT module of the human CCR4-NOT complex. Nature Structural and Molecular Biology 20 (11), pp. 1289 - 1297 (2013)

Loh, B.; Jonas, S.; Izaurralde, E.: The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes and Development 27 (19), pp. 2125 - 2138 (2013)

Nishihara, T.; Zekri, L.; Braun, J.; Izaurralde, E.: miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Research (London) 41 (18), pp. 8692 - 8705 (2013)

Christie, M.; Boland, A.; Huntzinger, E.; Weichenrieder, O.; Izaurralde, E.: Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Molecular Cell 5 (3), pp. 360 - 373 (2013)

Zekri, L.; Kuzuoğlu-Öztürk, D.; Izaurralde, E.: GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO Journal 32 (7), pp. 1052 - 1065 (2013)

Bawankar, P.; Loh, B.; Wohlbold, L.; Schmidt, S.; Izaurralde, E.: NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biology 10 (2), pp. 228 - 244 (2013)

Huntzinger, E.; Kuzuoğlu-Öztürk, D.; Braun, J.; Eulalio, A.; Wohlbold, L.; Izaurralde, E.: The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Research (London) 41 (2), pp. 978 - 994 (2013)

Jonas, S.; Weichenrieder, O.; Izaurralde, E.: An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes and Development 27 (2), pp. 211 - 225 (2013)

Braun, J.; Huntzinger, E.; Izaurralde, E.: A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harbor Perspectives in Biology 4 (12), a012328 (2012)

Braun, J.; Truffault, V.; Boland, A.; Huntzinger, E.; Chang, C.-T.; Haas, G.; Weichenrieder, O.; Coles, M.; Izaurralde, E.: A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nature Structural and Molecular Biology 19 (12), pp. 1324 - 1331 (2012)

Petit, A.-P.; Wohlbold, L.; Bawankar, P.; Huntzinger, E.; Schmidt, S.; Izaurralde, E.; Weichenrieder, O.: The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Research (London) 40 (21), pp. 11058 - 11072 (2012)

Izaurralde, E.: Elucidating the temporal order of silencing. EMBO Reports 13 (8), pp. 662 - 663 (2012)

Kuzuoğlu-Öztürk, D.; Huntzinger, E.; Schmidt, S.; Izaurralde, E.: The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Research (London) 40 (12), pp. 5651 - 5665 (2012)