DSSS - The origins and endpoints of cell-in-cell symbioses

  • Date: Mar 6, 2023
  • Time: 03:00 PM - 04:00 PM (Local Time Germany)
  • Speaker: Dr. John McCutcheon
  • Evolutionary cell biology and symbiosis, Howard Hughes Medical Institute, Arizona State University
  • Location: NO.002, MPI für Intelligente Systeme
 DSSS - The origins and endpoints of cell-in-cell symbioses

Mitochondria and chloroplasts are now called organelles, but they used to be bacteria. While a great deal is known about how organelles work in modern cells, understanding the genetic, biochemical, and cell biological events that happened during the transition from 'bacterial endosymbiont' to 'organelle’ is obscured by both time and by a lack of comparative examples. Surprisingly, some of the best comparative models for organelle formation to emerge in the last ten years are the bacterial endosymbionts of sap-feeding insects. My lab has been trying to understand how these insect endosymbionts originate, how they function with such small gene sets, and how they become integrated into the cell biology of their host cells. I will show examples of endosymbioses at various ages of integration, from young to old, and discuss how these results might be used to better understand of cell-in-cell relationships.

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