Publications
52. Chen, Y., Khazina, E., Izaurralde, E. and *Weichenrieder, O. (2021) Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex. Nucleic Acids Res, 49, 6489-6510.
51. *Weichenrieder, O. (2021) Cellular Traffic Jam and Disease Due to Mutations in SRP54. Structure, 29, 3-5.
50. Keskeny, C., Raisch, T., Sgromo, A., Igreja, C., *Bhandari, D., *Weichenrieder, O. and Izaurralde, E. (2019) A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex. Genes Dev, 33, 236-252.
49. Khazina, E. and *Weichenrieder, O. (2018) Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p. eLife, 7, e34960.
48. Raisch, T., Sandmeir, F., Weichenrieder, O., Valkov, E. and Izaurralde, E. (2018) Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex. J Struct Biol, 204, 388-395.
47. Sgromo, A., Raisch, T., Backhaus, C., Keskeny, C., Alva, V., Weichenrieder, O. and Izaurralde, E. (2018) Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. RNA, 24, 381-395.
46. MacLennan, M., García-Cañadas, M., Reichmann, J., Khazina, E., Wagner, G., Playfoot, C.J., Salvador-Palomeque, C., Mann, A.R., Peressini, P., Sanchez, L. Dobie, K., Read, D., Hung, C. C., Eskeland, R., Meehan, R. R., *Weichenrieder, O., *García- Pérez, J. L., *Adams, I. R. (2017) Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. eLife, 6, e26152.
45. Valkov, E., *Jonas, S. and *Weichenrieder, O. (2017) Mille viae in eukaryotic mRNA decapping. Curr Opin Struct Biol, 47, 40-51.
44. Sgromo, A., Raisch, T., Bawankar, P., Bhandari, D., Chen, Y., Kuzuoğlu-Öztürk, D., Weichenrieder, O. and Izaurralde, E. (2017) A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Nat Commun, 8, e14307.
43. Grüner, S., Peter, D., Weber, R., Wohlbold, L., Chung, M.Y., *Weichenrieder, O., Valkov, E., Igreja, C. and *Izaurralde, E. (2016) The Structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation. Molecular Cell, 64, 467-479.
42. Valkov, E., Muthukumar, S., Chang, C.T., *Jonas, S., *Weichenrieder, O. and *Izaurralde, E. (2016) Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. Nat Struct Mol Biol, 23, 574-579.
41. Raisch, T., Bhandari, D., Sabath, K., Helms, S., Valkov, E., *Weichenrieder, O. and *Izaurralde, E. (2016) Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. EMBO J, 35, 974-990.
40. Ahl, V., Keller, H., Schmidt, S. and *Weichenrieder, O. (2015) Retrotransposition and crystal structure of an Alu RNP in the ribosome-stalling conformation. Molecular Cell, 60, 715-727.
39. Peter, D., Weber, R., Kone, C., Chung, M.Y., Ebertsch, L., Truffault, V., Weichenrieder, O., Igreja, C. and Izaurralde, E. (2015) Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Genes & Development, 29, 1835-1849.
38. Peter, D., Igreja, C., Weber, R., Wohlbold, L., Weiler, C., Ebertsch, L., *Weichenrieder, O. and *Izaurralde, E. (2015) Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Molecular Cell, 57, 1074-1087.
37. Weinert, T., Olieric, V., Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J., Ebihara, A., Kuramitsu, S., Li, D., Howe, N., Schnapp, G., Pautsch, A., Bargsten, K., Prota, A. E., Surana, P., Kottur, J., Nair, D. T., Basilico, F., Cecatiello, V., Pasqualato, S., Boland, A., Weichenrieder, O., Wang, B. C., Steinmetz, M. O., Caffrey, M., Wang, M. (2015) Fast native-SAD phasing for routine macromolecular structure determination. Nature Methods, 12, 131-133.
36. Jonas, S., Christie, M., Peter, D., Bhandari, D., Loh, B., Huntzinger, E., *Weichenrieder, O. and *Izaurralde, E. (2014) An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nat Struct Mol Biol, 21, 599-608.
35. *Weichenrieder, O. (2014) RNA binding by Hfq and ring-forming (L)Sm proteins: a trade-off between optimal sequence readout and RNA backbone conformation. RNA Biology, 11, 537-549.
34. Chen, Y., Boland, A., Kuzuoğlu-Öztürk, D., Bawankar, P., Loh, B., Chang, C.T., *Weichenrieder, O. and *Izaurralde, E. (2014) A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Molecular Cell, 54, 737-750.
33. Bhandari, D., Raisch, T., Weichenrieder, O., Jonas, S. and Izaurralde, E. (2014) Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes & Development, 28, 888-901.
32. Boland, A., Chen, Y., Raisch, T., Jonas, S., Kuzuoğlu-Öztürk, D., Wohlbold, L., *Weichenrieder, O. and *Izaurralde, E. (2013) Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol, 20, 1289-1297.
31. Schneider, A.M., Schmidt, S., Jonas, S., Vollmer, B., Khazina, E. and *Weichenrieder, O. (2013) Structure and properties of the esterase from non-LTR retrotransposons suggest a role for lipids in retrotransposition. Nucleic Acids Res, 41, 10563-10572.
30. Christie, M., Boland, A., Huntzinger, E., *Weichenrieder, O. and *Izaurralde, E. (2013) Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Molecular Cell, 51, 360-373.
29. Jonas, S., Weichenrieder, O. and *Izaurralde, E. (2013) An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes & Development, 27, 211-225.
28. Braun, J.E., Truffault, V., Boland, A., Huntzinger, E., Chang, C.T., Haas, G., Weichenrieder, O., Coles, M. and Izaurralde, E. (2012) A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol, 19, 1324-1331.
27. Petit, A.P., Wohlbold, L., Bawankar, P., Huntzinger, E., Schmidt, S., *Izaurralde, E. and *Weichenrieder, O. (2012) The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res, 40, 11058-11072.
26. Sauer, E., Schmidt, S. and *Weichenrieder, O. (2012) Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition. Proc Natl Acad Sci U S A, 109, 9396-9401.
25. Khazina, E., Truffault, V., Büttner, R., Schmidt, S., Coles, M. and *Weichenrieder, O. (2011) Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition. Nat Struct Mol Biol, 18, 1006-1014.
24. Sauer, E. and *Weichenrieder, O. (2011) Structural basis for RNA 3'-end recognition by Hfq. Proc Natl Acad Sci U S A, 108, 13065-13070.
23. Boland, A., Huntzinger, E., Schmidt, S., *Izaurralde, E. and *Weichenrieder, O. (2011) Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A, 108, 10466-10471.
22. Braun, J.E., Tritschler, F., Haas, G., Igreja, C., Truffault, V., *Weichenrieder, O. and *Izaurralde, E. (2010) The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J, 29, 2368-2380.
21. Boland, A., Tritschler, F., Heimstädt, S., *Izaurralde, E. and *Weichenrieder, O. (2010) Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep, 11, 522-527.
20. Tritschler, F., Braun, J.E., Motz, C., Igreja, C., Haas, G., Truffault, V., *Izaurralde, E. and *Weichenrieder, O. (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A, 106, 21591-21596.
19. Fernández-Santiago, R., Hoenig, S., Lichtner, P., Sperfeld, A. D., Sharma, M., Berg, D., Weichenrieder, O. Illig, T., Eger, K., Meyer, T., Anneser, J., Münch, C., Zierz, S., Gasser, T., Ludolph, A. (2009) Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. J Neurol, 256, 1337-1342.
18. Eulalio, A., Tritschler, F., Büttner, R., Weichenrieder, O., Izaurralde, E. and Truffault, V. (2009) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res, 37, 2974-2983.
17. Tritschler, F., Braun, J.E., Eulalio, A., Truffault, V., *Izaurralde, E. and *Weichenrieder, O. (2009) Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Molecular Cell, 33, 661-668.
16. Khazina, E. and *Weichenrieder, O. (2009) Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame. Proc Natl Acad Sci U S A, 106, 731-736.
15. Bennett, E.A., Keller, H., Mills, R.E., Schmidt, S., Moran, J.V., Weichenrieder, O. and Devine, S.E. (2008) Active Alu retrotransposons in the human genome. Genome Res, 18, 1875-1883.
14. Tritschler, F., Eulalio, A., Helms, S., Schmidt, S., Coles, M., Weichenrieder, O., Izaurralde, E. and Truffault, V. (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol, 28, 6695-6708.
13. Tritschler, F., Eulalio, A., Truffault, V., Hartmann, M.D., Helms, S., Schmidt, S., Coles, M., *Izaurralde, E. and *Weichenrieder, O. (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol, 27, 8600-8611.
12. Repanas, K., Zingler, N., Layer, L.E., Schumann, G.G., Perrakis, A. and *Weichenrieder, O. (2007) Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease. Nucleic Acids Res, 35, 4914-4926.
11. Müller, M., Weigand, J.E., *Weichenrieder, O. and *Suess, B. (2006) Thermodynamic characterization of an engineered tetracycline-binding riboswitch. Nucleic Acids Res, 34, 2607-2617.
10. Buchwald, G., van der Stoop, P., Weichenrieder, O., Perrakis, A., van Lohuizen, M. and Sixma, T.K. (2006) Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J, 25, 2465-2474.
9. Zingler, N., Weichenrieder, O. and Schumann, G.G. (2005) APE-type non-LTR retrotransposons: determinants involved in target site recognition. Cytogenet Genome Res, 110, 250-268.
8. *Weichenrieder, O., Repanas, K. and *Perrakis, A. (2004) Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon. Structure, 12, 975-986.
7. Huck, L., Scherrer, A., Terzi, L., Johnson, A.E., Bernstein, H.D., Cusack, S., Weichenrieder, O. and Strub, K. (2004) Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain. Nucleic Acids Res, 32, 4915-4924.
6. Wild, K., Weichenrieder, O., Strub, K., Sinning, I. and Cusack, S. (2002) Towards the structure of the mammalian signal recognition particle. Curr Opin Struct Biol, 12, 72-81.
5. Weichenrieder, O., Stehlin, C., Kapp, U., Birse, D.E., Timmins, P.A., Strub, K. and Cusack, S. (2001) Hierarchical assembly of the Alu domain of the mammalian signal recognition particle. RNA, 7, 731-740.
4. Weichenrieder, O., Wild, K., Strub, K. and Cusack, S. (2000) Structure and assembly of the Alu domain of the mammalian signal recognition particle. Nature, 408, 167-173.
3. Wild, K., Weichenrieder, O., Leonard, G.A. and Cusack, S. (1999) The 2 Å structure of helix 6 of the human signal recognition particle RNA. Structure, 7, 1345-1352.
2. Weichenrieder, O., Kapp, U., Cusack, S. and Strub, K. (1997) Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14. RNA, 3, 1262-1274.
1. Jones, J.T., Barnes, C.L., Lietzke, S.E., Weichenrieder, O., Doudna, J.A. and Kundrot, C.E. (1996) Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase. Acta Crystallogr D Biol Crystallogr, 52, 1018-1020.