Publications
_{Microbiome Lipid Metabolism}

Klag, K.; Ott, D.; Tippetts, S.; Nicolson, R.; Tatum, S.; Bauer, K.; Stephen-Victor, E.; Weis, A.; Bell, R.; Weagley, J. et al.; Maschek, A.; Vu, D.; Heaver, S.; Ley, R.; O'Connell, R.; Holland, W.; Summers, S.; Stephens, W.; Round, J.: Dietary fat disrupts a commensal-host lipid network that promotes metabolic health. Cell Metabolism Epub ahead (2025)

Fuentes, J.; Singh, S.; Pudlo, N.; Heaver, S.; Ley, R.; Martens, E.: Carbohydrates and the oxidative branch of the pentose phosphate pathway modify Bacteroides thetaiotaomicron phage resistance by phase variable S-layers. Journal of Bacteriology 207 (10), e0017825 (2025)

Kim, S.-G.; Ott, R.; Bretin, A.; Abo, H.; Wang, Y.; Wang, Y.; Winer, S.; Winer, D.; Reddivari, L.; Heaver, S. et al.; Ley, R.; Pellizzon, M.; Ngo, V.; Gewirtz, A.: Wheat Fiber Suppresses Development of Colitis via Microbiota-Mediated Fermentation-Independent Metabolites that Reprogram Intestinal Macrophages. Cell Host & Microbe (accepted)

Winsor, N.; Bayer, G.; Singh, O.; Chan, J.; Li, L.; Lieng, B.; Foerster, E.; Popovic, A.; Tsankov, B.; Maughan, H. et al.; Lemire, P.; Tam, E.; Streutker, C.; Chen, L.; Heaver, S.; Ley, R.; Parkinson, J.; Montenegro-Burke, J.; Birchenough, G.; Philpott, D.; Girardin, S.: Cross-kingdom-mediated detection of intestinal protozoa through NLRP6. Cell Host & Microbe 33 (3), pp. 388 - 407 (2025)

Mirretta Barone, C.; Heaver, S.; Gruber, L.; Zundel, F.; Vu, D.; Ley, R.: Spatially resolved lipidomics shows conditional transfer of lipids produced by Bacteroides thetaiotaomicron into the mouse gut. Cell Host & Microbe 32 (6), pp. 1025 - 1036 (2024)

Heaver, S.; He, H.; Tang, P.; Baslé, A.; Mirretta Barone, C.; Vu, D.; Waters, J.; Marles-Wright, J.; Johnson, E.; Campopiano, D. et al.; Ley, R.: Characterization of inositol lipid metabolism in gut-associated Bacteroidetes. Nature Microbiology 7 (7), pp. 986 - 1000 (2022)

Johnson, E.; Heaver, S.; Waters, J.; Kim, B.; Bretin, A.; Goodman, A.; Gewirtz, A.; Worgall, T.; Ley, R.: Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels. Nature Communications 11, 2471 (2020)

Heaver, S.; Johnson, E.; Ley, R.: Sphingolipids in host-microbial interactions. Current Opinion in Microbiology 43, pp. 92 - 99 (2018)

Johnson, E.; Heaver, S.; Walters, W.; Ley, R.: Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes. Journal of Molecular Medicine 95 (1), pp. 1 - 8 (2017)

Heaver, S.: Sphingolipids in host-microbial interactions in the mammalian gut. In Annual Conference of the Microbiology Society 2021. Annual Conference of the Microbiology Society 2021, April 26, 2021 - April 30, 2021. (2021)

Heaver, S.; Vu, D.; Bryson, A.; Ley, R.: A parallel pathway for inositol sphingolipid synthesis in gut Bacteroidota. 75th Mosbacher Kolloquium "The Microbiome - from Understanding to Modulation", Mosbach, Germany (2024)

Heaver, S.; Vu, D.; Laugner, S.; Ley, R.: A novel parallel pathway for inositol sphingolipid synthesis in gut Bacteroidota. 3rd International Conference Controlling Microbes to Fight Infections (CMFI 2023), Tübingen, Germany (2023)

Heaver, S.; Vu, D.; Laugner, S.; Ley, R.: A novel parallel pathway for inositol sphingolipid synthesis in gut Bacteroidetes. Cell Symposia: Infection Biology in the Age of the Microbiome, Paris, France (2023)

Frick, C.; Gruber, L.; Zundel, F; Heaver, S.; Ley, R.: Spatial lipid profiling of the gut commensal B. thetaiotaomicron in the mouse gut. OurCon2021: The International Mass Spectrometry Imaging Conference, Sheffield, UK (2021)

Heaver, S.; Ley, R.: A transcriptomic approach to identify the sphingolipid metabolic pathway in gut-associated Bacteroides. 13th Sphingolipid Club & 10th International Ceramide Conference, Cascais, Portugal (2019)

Heaver, S.: Characterization and exploration of the rationale for sphingolipid metabolism in host-associated Bacteroides. Dissertation, 172 pp., Cornell University: Department of Microbiology, Ithaca, NY, USA (2020)